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Expression patterns of gdnf and gfrα1 in rainbow trout testis.
https://oacis.repo.nii.ac.jp/records/1639
https://oacis.repo.nii.ac.jp/records/1639bf8b0abd-eac2-4854-bc8d-f0956202de96
名前 / ファイル | ライセンス | アクション |
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25114005_GEP_14-2-111 (946.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-12-25 | |||||
タイトル | ||||||
タイトル | Expression patterns of gdnf and gfrα1 in rainbow trout testis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | GDNF, GFRα1, Rainbow trout, Spermatogenesis, Spermatogonial stem cell | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Satoshi Nakajima
× Satoshi Nakajima× Makoto Hayashi× Tomomi Kouguchi× Kazuma Yamaguchi× Misako Miwa× Yoshizaki, Goro |
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書誌情報 |
Gene Expression Patterns 巻 14, 号 2, p. 111-120, 発行日 2014-03 |
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抄録 | ||||||
内容記述 | In mice, glial cell line-derived neurotrophic factor (GDNF) is essential for normal spermatogenesis and in vitro culture of spermatogonial stem cells. In murine testes, GDNF acts as paracrine factor; Setoli cells secrete it to a subset of spermatogonial cells expressing its receptor, GDNF family receptor α1 (GFRα1). However, in fish, it is unclear what types of cells express gdnf and gfrα1. In this study, we isolated the rainbow trout orthologues of these genes and analyzed their expression patterns during spermatogenesis. In rainbow trout testes, gdnf and gfrα1 were expressed in almost all type A spermatogonia (ASG). Noticeably, unlike in mice, the expression of gdnf was not observed in Sertoli cells in rainbow trout. During spermatogenesis, the expression levels of these genes changed synchronously; gdnf and gfrα1 showed high expression in ASG and decreased dramatically in subsequent developmental stages. These results suggested that GDNF most likely acts as an autocrine factor in rainbow trout testes. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1567133X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11800332 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 24518650 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.gep.2014.01.006 | |||||
権利 | ||||||
権利情報 | (c) 2014, Elsevier B.V.. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in https://doi.org/10.1016/j.gep.2014.01.006 | |||||
情報源 | ||||||
関連識別子 | https://doi.org/10.1016/j.gep.2014.01.006 | |||||
関連名称 | Publisher's Version/PDF | |||||
情報源 | ||||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-25114005/ | |||||
関連名称 | KAKEN研究課題: サケ科魚類の進化に伴うGSC制御機構の変化 | |||||
情報源 | ||||||
関連識別子 | https://nrid.nii.ac.jp/ja/nrid/1000070281003/ | |||||
関連名称 | 研究代表者: 吉崎 悟朗 (東京海洋大学) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
件名 | ||||||
主題 | 科学研究費研究成果 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
科学研究費研究課題 | ||||||
主題 | サケ科魚類の進化に伴うGSC制御機構の変化 | |||||
科学研究費研究課題 | ||||||
主題 | Evolution of GSC regulation in salmonids Planned | |||||
研究課題番号 | ||||||
内容記述 | 25114005 |