{"created":"2023-07-25T09:58:31.208961+00:00","id":1639,"links":{},"metadata":{"_buckets":{"deposit":"32a0bce1-aa4e-4aa6-bd84-aeb2488c7009"},"_deposit":{"created_by":15,"id":"1639","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"1639"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00001639","sets":["187:191:245","41:278","70:270"]},"author_link":["2720","2721","2706","2703","2719","1557"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"120","bibliographicPageStart":"111","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Gene Expression Patterns"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In mice, glial cell line-derived neurotrophic factor (GDNF) is essential for normal spermatogenesis and in vitro culture of spermatogonial stem cells. In murine testes, GDNF acts as paracrine factor; Setoli cells secrete it to a subset of spermatogonial cells expressing its receptor, GDNF family receptor α1 (GFRα1). However, in fish, it is unclear what types of cells express gdnf and gfrα1. In this study, we isolated the rainbow trout orthologues of these genes and analyzed their expression patterns during spermatogenesis. In rainbow trout testes, gdnf and gfrα1 were expressed in almost all type A spermatogonia (ASG). Noticeably, unlike in mice, the expression of gdnf was not observed in Sertoli cells in rainbow trout. During spermatogenesis, the expression levels of these genes changed synchronously; gdnf and gfrα1 showed high expression in ASG and decreased dramatically in subsequent developmental stages. These results suggested that GDNF most likely acts as an autocrine factor in rainbow trout testes."}]},"item_3_description_63":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"25114005"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_3_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{}}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.gep.2014.01.006","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.gep.2014.01.006","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN研究課題: サケ科魚類の進化に伴うGSC制御機構の変化"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-25114005/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"研究代表者: 吉崎 悟朗 (東京海洋大学)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://nrid.nii.ac.jp/ja/nrid/1000070281003/","subitem_relation_type_select":"URI"}}]},"item_3_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2014, Elsevier B.V.. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in https://doi.org/10.1016/j.gep.2014.01.006"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1567133X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11800332","subitem_source_identifier_type":"NCID"}]},"item_3_subject_62":{"attribute_name":"件名","attribute_value_mlt":[{"subitem_subject":"科学研究費研究成果"}]},"item_3_subject_64":{"attribute_name":"科学研究費研究課題","attribute_value_mlt":[{"subitem_subject":"サケ科魚類の進化に伴うGSC制御機構の変化"},{"subitem_subject":"Evolution of GSC regulation in salmonids Planned"}]},"item_3_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoshi Nakajima"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makoto Hayashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomomi Kouguchi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kazuma Yamaguchi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Misako Miwa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Goro"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-12"}],"displaytype":"detail","filename":"25114005_GEP_14-2-111.pdf","filesize":[{"value":"946.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"25114005_GEP_14-2-111","url":"https://oacis.repo.nii.ac.jp/record/1639/files/25114005_GEP_14-2-111.pdf"},"version_id":"350fb667-0c15-4ad5-b257-92fce02e127b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GDNF","subitem_subject_scheme":"Other"},{"subitem_subject":"GFRα1","subitem_subject_scheme":"Other"},{"subitem_subject":"Rainbow trout","subitem_subject_scheme":"Other"},{"subitem_subject":"Spermatogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Spermatogonial stem cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Expression patterns of gdnf and gfrα1 in rainbow trout testis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression patterns of gdnf and gfrα1 in rainbow trout testis."}]},"item_type_id":"3","owner":"15","path":["245","270","278"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-25"},"publish_date":"2018-12-25","publish_status":"0","recid":"1639","relation_version_is_last":true,"title":["Expression patterns of gdnf and gfrα1 in rainbow trout testis."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:45:02.076146+00:00"}