{"created":"2023-07-25T09:59:16.822338+00:00","id":2567,"links":{},"metadata":{"_buckets":{"deposit":"1366eba5-f452-47e3-bc89-529848f8c226"},"_deposit":{"created_by":15,"id":"2567","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2567"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002567","sets":["187:189:299","187:191:238","41:428"]},"author_link":["4065","4064","1548","1744"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"104195","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"Developmental & Comparative Immunology"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mycobacteriosis caused by Mycobacterium spp. causes economic damages to the world aquaculture industry.\nIn mammals, mycolic acids contained in the cell wall of Mycobacterium spp. are presented by CD1b molecule as lipid antigens and induce cell-mediated immunity (CMI).\nHere, we investigated CMI responses against the mycolic acids of Mycobacterioides salmoniphilum in a CD1-lacking teleost fish, rainbow trout.\nAfter stimulation of trout leukocytes with mycolic acids, the number and percentage of CD8α+ T cells increased.\nFish immunized with mycolic acids showed an up-regulation of IFN-γ. Further, in vitro re-stimulation of leukocytes derived from immunized fish resulted in proliferation of CD8α+ cells.\nThese data suggest that mycolic acids are recognized as lipid antigens resulting in an activation of rainbow trout CD8α+ cells and up-regulation of the Th1 cytokine IFN-γ.\nThe mycolic acids are promising candidates for vaccines to activate CD8α+ T cells against fish mycobacteriosis."}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"公開日: 2022-07-05"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_3_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{}}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.dci.2021.104195","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Author's Accepted Manuscript Version/PDF (Available on: 2022-07-05) "}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/am/pii/S0145305X21002032","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Elsevier B.V."}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.elsevier.com/ja-jp","subitem_relation_type_select":"URI"}}]},"item_3_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2021 Elsevier B.V.. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in https://doi.org/10.1016/j.dci.2021.104195"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0145-305X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00627870","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fischer, Uwe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sano, Motohiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kato, Goshi"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mycobacteriosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Rainbow trout","subitem_subject_scheme":"Other"},{"subitem_subject":"Mycolic acids","subitem_subject_scheme":"Other"},{"subitem_subject":"Mycobacteroides salmoniphilum","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell-mediated immunity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Cell-mediated immune response against mycolic acids of Mycobacteroides salmoniphilum in rainbow trout Oncorhynchus mykiss","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cell-mediated immune response against mycolic acids of Mycobacteroides salmoniphilum in rainbow trout Oncorhynchus mykiss"}]},"item_type_id":"3","owner":"15","path":["238","299","428"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-26"},"publish_date":"2022-09-26","publish_status":"0","recid":"2567","relation_version_is_last":true,"title":["Cell-mediated immune response against mycolic acids of Mycobacteroides salmoniphilum in rainbow trout Oncorhynchus mykiss"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:29:08.896235+00:00"}