{"created":"2023-07-25T09:59:08.653362+00:00","id":2388,"links":{},"metadata":{"_buckets":{"deposit":"e58b56c7-c523-4f67-a77c-4de124ef275c"},"_deposit":{"created_by":15,"id":"2388","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2388"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002388","sets":["187:189:555","41:619"]},"author_link":["1991","1927","3515","3781"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"87","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Marine Drugs"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study aimed to investigate the protective effect of the metabolites produced by a new Lactiplantibacillus plantarum strain BF1-13, isolated from deep seawater (DSW), on the intestinal epithelial barrier against the dysfunction induced by hydrogen peroxide (H2O2) and to elucidate the mechanism underlying the effect.\nProtective effect of the metabolites by strain BF1-13 on the barrier function of the intestinal epithelial model treated with H2O2 was investigated by the transepithelial electrical resistance (TEER).\nThe metabolites enhanced the Claudin-4 (CLDN-4) expression, including at the transcription level, indicated by immunofluorescence staining and quantitative RT-PCR. The metabolites also showed a suppression of aquaporin3 (AQP3) expression. Lactic acid (LA) produced by this strain of homofermentative lactic acid bacteria (LAB) had a similar enhancement on CLDN-4 expression.\nThe metabolites of L. plantarum strain BF1-13 alleviated the dysfunction of intestinal epithelial barrier owing to its enhancement on the tight junctions (TJs) by LA, along with its suppression on AQP3-facilitating H2O2 intracellular invasion into Caco-2 cells. This is the first report on the enhancement of TJs by LA produced by LAB. "}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/md20020087","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/md20020087","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"MDPI"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/","subitem_relation_type_select":"URI"}}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1203626X","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Diao, Xiaozhen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Katsuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴田, 雄次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imada, Chiaki"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lactiplantibacillus plantarum","subitem_subject_scheme":"Other"},{"subitem_subject":"deep seawater","subitem_subject_scheme":"Other"},{"subitem_subject":"tight junctions","subitem_subject_scheme":"Other"},{"subitem_subject":"aquaporin3","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrogen peroxide","subitem_subject_scheme":"Other"},{"subitem_subject":"lactic acid","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide"}]},"item_type_id":"3","owner":"15","path":["555","619"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-08"},"publish_date":"2022-04-08","publish_status":"0","recid":"2388","relation_version_is_last":true,"title":["Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:32:09.652803+00:00"}