@article{oai:oacis.repo.nii.ac.jp:00002387,
 author = {Harunari, Enjuro and Imada, Chiaki and Igarashi, Yasuhiro and Fukuda, Takao and Terahara, Takeshi and Kobayashi, Takeshi},
 issue = {1},
 journal = {Marine Drugs},
 month = {Jan},
 note = {Hyaluromycin (1), a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived Streptomyces sp. as a HAase inhibitor on the basis of HAase activity screening. The structure of 1 was elucidated through the interpretation of NMR data for the compound and its 3″-O-methyl derivative in combination with an incorporation experiment with [1,2-13C2]acetate.
The compound’s absolute configuration was determined by the comparison of its circular dichroism (CD) spectrum with those of other rubromycins.
Hyaluromycin (1) consists of a γ-rubromycin core structure possessing a 2-amino-3-hydroxycyclopent-2-enone (C5N) unit as an amide substituent of the carboxyl function; both structural units have been reported only from actinomycetes. Hyaluromycin (1) displayed approximately 25-fold more potent hyaluronidase inhibitory activity against hyaluronidase than did glycyrrhizin, a known inhibitor of plant origin.},
 pages = {491--507},
 title = {Hyaluromycin, a New Hyaluronidase Inhibitor of Polyketide Origin from Marine Streptomyces sp.},
 volume = {12},
 year = {2014}
}