{"created":"2023-07-25T09:59:08.141898+00:00","id":2377,"links":{},"metadata":{"_buckets":{"deposit":"13c08fcc-bb42-4107-8b4e-296d74305827"},"_deposit":{"created_by":15,"id":"2377","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2377"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002377","sets":["187:189:555","187:189:558","41:618"]},"author_link":["1991","3699","2513","269","3763","3697"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"17","bibliographicPageStart":"11","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"海洋深層水研究"},{"bibliographic_title":"Deep Ocean Water Research","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"コラーゲンは美容を考えるうえで重要な真皮マトリックス成分の一つで、その合成にはビタミンCが必要である. \n著者らは,ビタミンCの存在下で、ヒトの皮膚由来の線維芽細胞 (以下, NB1)を伊豆半島赤沢 (水深800m) から取水されている海洋深層水 (以下, DSW) とその直上の表面海水 (以下, SSW) を添加した培地で培養し、コラーゲンタンパク質(以下, コラーゲン) の合成量の違いを調べた. \nその結果, SSW では対照区であるSSW無添加区と比べ1.1倍に上昇したコラーゲン合成量が, DSWではDSW無添加区と比べ1.9倍と、SSWと比較し顕著に上昇した. \nさらに、DSW 添加区のNB1ではI型コラーゲンタンパク質遺伝子 (COL1) の発現が早まることが判明した。"},{"subitem_description":"Collagen is an important composition of skin matrix to paid attention in cosmetology. \nIn the present study, effects of deep seawater on the synthesis of collagen in fibroblasts from human skins (NBI) were examined in culture. The fibroblasts were cultured in the presence of vitamin C (20μg/mL) with 0 to 20% deep seawater (DSW) pumped from a depth of 800m (5km offshore) and in surface seawater (SSW) collected directly at the sea surface off Akazawa in Izu Peninsula, Shizuoka Prefecture, Japan.\nAs a result, the collagen synthesis rose to 1.1 times in SSW compared with no added SSW. In contrast, the collagen synthesis remarkably rose to 1.9 times in DSW compared with no additive DSW.\nOther observations made during this study suggest that DSW promotes the expression of genes involved in Type I collagen synthesis (COLI) in the early stage in fibroblasts cultured with vitamin C."}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"海洋深層水利用学会"}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.12.11","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.12.11","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"海洋深層水利用学会"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dowas.net/index.html","subitem_relation_type_select":"URI"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-8477","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11858274","subitem_source_identifier_type":"NCID"}]},"item_3_text_61":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"バイヨウ ヒト センイガ サイボウ ノ コラーゲン ゴウセイ ニ タイスル イズ アカザワ カイヨウ シンソウスイ ノ コウカ"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野村, 道康"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"有賀, みずえ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 勝久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今田, 千秋"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小林, 武志"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI"}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"佐藤, 奈保子 ","creatorNameLang":"ja"},{"creatorName":"サトウ, ナオコ","creatorNameLang":"ja"},{"creatorName":"Hamada, Naoko","creatorNameLang":"en"},{"creatorName":"濱田, 奈保子 ","creatorNameLang":"ja"},{"creatorName":"ハマダ, ナオコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyNameLang":"ja"},{"familyNameLang":"ja"},{"familyNameLang":"en"},{"familyNameLang":"ja"},{"familyNameLang":"ja-Kana"}],"givenNames":[{"givenNameLang":"ja"},{"givenNameLang":"ja"},{"givenNameLang":"en"},{"givenNameLang":"ja"},{"givenNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"伊豆赤沢","subitem_subject_scheme":"Other"},{"subitem_subject":"海洋深層水","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン合成","subitem_subject_scheme":"Other"},{"subitem_subject":"COLI","subitem_subject_scheme":"Other"},{"subitem_subject":"Izu-Akazawa","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"deep seawater","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen synthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"COL1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"培養ヒト線維芽細胞のコラーゲン合成に対する伊豆赤沢海洋深層水の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"培養ヒト線維芽細胞のコラーゲン合成に対する伊豆赤沢海洋深層水の効果"},{"subitem_title":"Effects of deep seawater pumped at Izu-Akazawa on collagen synthesis in cultured human fibroblasts","subitem_title_language":"en"}]},"item_type_id":"3","owner":"15","path":["555","558","618"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-05"},"publish_date":"2022-04-05","publish_status":"0","recid":"2377","relation_version_is_last":true,"title":["培養ヒト線維芽細胞のコラーゲン合成に対する伊豆赤沢海洋深層水の効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-04-02T08:13:08.552810+00:00"}