{"created":"2023-07-25T09:59:07.998343+00:00","id":2374,"links":{},"metadata":{"_buckets":{"deposit":"4ae0be4f-1c50-4651-b757-0188b5f49d11"},"_deposit":{"created_by":15,"id":"2374","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2374"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002374","sets":["187:189:555","41:618"]},"author_link":["1991","3697"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"海洋深層水研究"},{"bibliographic_title":"Deep Ocean Water Research","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"地球上のすべての生命が海洋に誕生したことは，今や周知のとおりである．そしてまた，生体内に最初の骨を作った生命も海洋生物である．海洋生物が手にした骨形成機構は，生命の形を留めるのに有効であるだけではなく，群生構造物として地球環境を左右する造礁サンゴのような生物への進化を導いた.\nまた獲得した骨形成機構を，個体の中で巧みに骨格や歯など様々な骨に分化させて，やがて生命としての形の維持と行動における柔軟性を併せ持つ脊椎動物の誕生に至った．生命が生活環境の変化に呼応して進化する中で，体の様々な部位に骨を形成することができるのも，骨を作る細胞が未分化の状態で体中に分布していることに起因する．このことは生命が環境の変化に呼応して骨を形成する仕組みを獲得し，進化の階段を上り詰めてヒトにまで進化した証である．しかしこの骨形成機構には時々不具合が生じる．それは元来形成されない部位で骨が形成されてしまう，異所性石灰化という現象である．\n最近になって，培養細胞において紫外線がこの現象を誘導することが示された．したがってこの現象がヒトの皮膚でも起っている可能性が考えられる．本稿では無脊椎動物から脊椎動物への進化における骨形成機構の獲得を通して紫外線により生じる細胞のカルシウム蓄積現象について考察を行い，最後にこの現象に対する抑制手段として海洋深層水利用の可能性を書き添える．"},{"subitem_description":"It is well-known that the origin of the life was more likely to have occurred in the ocean. The mechanism of calcification developed by marine creatures was useful not only for determination of the shape of the body but also for the evolution into creatures such as hermatypic corals which play important roles in the marine environment by building reefs. Eventually, this process became osteogenesis, enabling the differentiation into various bones including oral teeth, which led to the evolution of vertebrate animals with high flexibility and physical mobility.\nIn evolutions of creatures with developing of their bones in response to various environments, it was undifferentiated osteogenic cells which enabled the evolution of bones in various parts of the body. In human evolution, this mechanisms of osteogenesis played an important role and it was maintained in the evolutionary process. Under normal circumstances, calcification only occurs in bone tissues; however this mechanism sometimes malfunctions. It is called an ectopic calcification in which calcium is deposited abnormally in soft tissues. Recently, it was shown that A wave of ultraviolet rays (UVA) irradiation induced this phenomenon in cultured cells.\nTherefore, it is considered that this phenomenon may be also caused in human skin. This review article is considered about a phenomenon of calcium accumulation induced by UVA irradiation in cultured human fibroblasts through the acquisition of osteogenesis mechanism in evolution from the invertebrate to the vertebrate. At the last, this review article describes about a possibilities for an application of deep seawater as a prevention method in regard to this phenomenon."}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"海洋深層水利用学会"}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.19.1","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.19.1","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"海洋深層水利用学会"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.dowas.net/","subitem_relation_type_select":"URI"}}]},"item_3_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"130007855539","subitem_relation_type_select":"NAID"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-8477","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11858274","subitem_source_identifier_type":"NCID"}]},"item_3_text_61":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"コツケイセイ キコウ ノ シンカ ト イショセイ セッカイカ : ウミ カラ ヒフ ヘノ アプローチ"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 勝久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今田, 千秋"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"石灰化","subitem_subject_scheme":"Other"},{"subitem_subject":"海洋深層水","subitem_subject_scheme":"Other"},{"subitem_subject":"生命の進化","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚","subitem_subject_scheme":"Other"},{"subitem_subject":"紫外線A波","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcification","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Deep seawater","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Evolution of the life","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"UVA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"骨形成機構の進化と異所性石灰化 : 海から皮膚へのアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨形成機構の進化と異所性石灰化 : 海から皮膚へのアプローチ"},{"subitem_title":"Evolution of osteogenesis and ectopic calcification : Approach from the sea to human skin","subitem_title_language":"en"}]},"item_type_id":"3","owner":"15","path":["555","618"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-01"},"publish_date":"2022-04-01","publish_status":"0","recid":"2374","relation_version_is_last":true,"title":["骨形成機構の進化と異所性石灰化 : 海から皮膚へのアプローチ"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:32:20.048880+00:00"}