{"created":"2023-07-25T09:59:07.934526+00:00","id":2373,"links":{},"metadata":{"_buckets":{"deposit":"f54d51ec-149c-4915-b00f-aa7c08924f2f"},"_deposit":{"created_by":15,"id":"2373","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2373"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002373","sets":["187:189:555","41:618"]},"author_link":["1927","3699","3697","1991","3758"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"海洋深層水研究"},{"bibliographic_title":"Deep Ocean Water Research","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は正常ヒト由来培養線維芽細胞（以後，NB1細胞）を用いてCa/Mg比に関する研究を行い，その増加が特に老化した細胞の活性を低下させることをすでに本誌で報告した．また本論文ではCa/Mg比の増加がNB1細胞の石灰化を促進し，さらにこの現象は細胞の老化に伴って顕著となることが示唆された．しかしながらこのような場合においても，伊豆赤沢海洋深層水の添加により，NB1細胞の石灰化が抑制されることがわかった．本研究の結果から，食の欧米化に伴いCa/Mg比が増加する傾向にある現代の日本の食餌において，海洋深層水の利用は細胞の石灰化を抑制する点で健康維持上，一つの有用なアプローチになると期待される．"},{"subitem_description":"We have previously reported in this journal that the increase of Ca/Mg ratio causes a decrease in cell viability of cultured normal human fibroblasts (NB1 cells), especially in aged cells.\nIn this report, the effect of aging of cells and an increase of Ca/Mg ratio on calcification was investigated.\nAs a result, it was shown that the calcification in NB1 cells was promoted by the increase of Ca/Mg ratio. Furthermore, the calcification advanced significantly with cell aging. Even in these cases, however, it was revealed that the calcification in cells was inhibited by the addition of deep seawater collected at the station of Izu-Akazawa, Japan. Considering these results, the application of deep seawater can be regarded as a promising approach to avoid the calcification of cells, because Ca/Mg ratio has been on the rise with the westernization of the contemporary Japanese diet."}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.17.1","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.17.1","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"海洋深層水利用学会"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.dowas.net/","subitem_relation_type_select":"URI"}}]},"item_3_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"130007855567","subitem_relation_type_select":"NAID"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-8477","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11858274","subitem_source_identifier_type":"NCID"}]},"item_3_text_61":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"カイヨウ シンソウスイ ハ Ca / Mg ヒ ノ ゾウカ ニ ヨル セイジョウ ヒト センイガサイボウ ノ セッカイカ オ ヨクセイ スル"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 勝久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 正宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野村, 道康"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴田, 雄次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今田, 千秋"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カルシウム","subitem_subject_scheme":"Other"},{"subitem_subject":"石灰化","subitem_subject_scheme":"Other"},{"subitem_subject":"海洋深層水","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"マグネシウム","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcification","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Deep seawater","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Magnesium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"海洋深層水はCa/Mg比の増加による 正常ヒト線維芽細胞の石灰化を抑制する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"海洋深層水はCa/Mg比の増加による 正常ヒト線維芽細胞の石灰化を抑制する"},{"subitem_title":"Deep seawater suppresses the calcification of normal human fibroblasts induced by the increase in the Ca/Mg ratio","subitem_title_language":"en"}]},"item_type_id":"3","owner":"15","path":["555","618"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-01"},"publish_date":"2022-04-01","publish_status":"0","recid":"2373","relation_version_is_last":true,"title":["海洋深層水はCa/Mg比の増加による 正常ヒト線維芽細胞の石灰化を抑制する"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:32:06.266295+00:00"}