{"created":"2023-07-25T09:59:07.868708+00:00","id":2372,"links":{},"metadata":{"_buckets":{"deposit":"39a894bf-c81b-436c-9541-c016176821c3"},"_deposit":{"created_by":15,"id":"2372","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2372"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002372","sets":["187:189:555","41:618"]},"author_link":["1991","1927","3699","3697"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"海洋深層水研究"},{"bibliographic_title":"Deep ocean water research","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は正常ヒト由来培養線維芽細胞（以後，NB1細胞）を用いてCa/Mg比の増加および細胞の老化がNB1細胞の石灰化を促進することを既に報告した．本研究では，培地中のCa/Mg比が2という生理的条件でも，長波長紫外線（UVA）の照射によりNB1細胞は石灰化することを確認した．さらに海洋深層水（以後，DSW）は，UVA照射により誘導されるNB1細胞の石灰化に対する抑制効果を示し，この効果は表面海水（以後，SSW）よりも高いことがわかった．これらの結果から，DSWが有する顕著な細胞石灰化抑制効果は，DSWに含まれる成分が示す特異的な作用である可能性が示唆された． "},{"subitem_description":"We have previously reported in this journal that the increase in Ca/Mg ratio and the aging of cells promote calcification of cultured normal human fibroblasts (NB1 cells). In this report, it is suggested that A-wave ultraviolet rays (UVA) induces calcification of NB1 cells even if the Ca/Mg ratio in culture medium is well balanced as 2. \nFurthermore, we have discovered that deep seawater (DSW) suppresses the calcification induced by UVA irradiation. In addition, suppressive effect of DSW was much higher than that of SSW. From these results, it was suggested that the suppressive effect of DSW on calci\u001ecation in NB1 cells was caused by specific components included in DSW."}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"海洋深層水利用学会"}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.18.1","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11174/dowas.18.1","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"海洋深層水利用学会"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.dowas.net/","subitem_relation_type_select":"URI"}}]},"item_3_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"130007855565","subitem_relation_type_select":"NAID"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-8477","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11858274","subitem_source_identifier_type":"NCID"}]},"item_3_text_61":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"UVA ショウシャ ニ ヨリ ユウドウ サレル セイジョウ ヒト センイガサイボウ ノ セッカイカ ニ タイスル カイヨウ シンソウスイ ノ ヨクセイ コウカ"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 勝久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴田, 雄次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野村, 道康"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今田, 千秋"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"石灰化","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウム","subitem_subject_scheme":"Other"},{"subitem_subject":"海洋深層水","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"紫外線A波","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcification","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Deep seawater","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"UVA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"UVA照射により誘導される正常ヒト線維芽細胞の石灰化に対する海洋深層水の抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"UVA照射により誘導される正常ヒト線維芽細胞の石灰化に対する海洋深層水の抑制効果"},{"subitem_title":"Suppressive effect of deep seawater on the calcification of normal human fibroblasts induced by UVA irradiation","subitem_title_language":"en"}]},"item_type_id":"3","owner":"15","path":["555","618"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-01"},"publish_date":"2022-04-01","publish_status":"0","recid":"2372","relation_version_is_last":true,"title":["UVA照射により誘導される正常ヒト線維芽細胞の石灰化に対する海洋深層水の抑制効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:32:05.426212+00:00"}