{"created":"2023-07-25T09:58:54.950493+00:00","id":2097,"links":{},"metadata":{"_buckets":{"deposit":"29217b63-862b-4856-be09-55a5abcee3d2"},"_deposit":{"created_by":15,"id":"2097","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2097"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00002097","sets":["187:189:208","187:189:531","187:191:207","187:191:236","187:191:245","187:191:416","187:191:419","41:499","70:498"]},"author_link":["3332","3331","2577","2178","1557","2995","1828","768","2351","3335","3334"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Communications Biology"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The colonisation of freshwater environments by marine fishes has historically been considered a result of adaptation to low osmolality. However, most marine fishes cannot synthesise the physiologically indispensable fatty acid, docosahexaenoic acid (DHA), due to incomplete DHA biosynthetic pathways, which must be adapted to survive in freshwater environments where DHA is poor relative to marine environments. By analysing DHA biosynthetic pathways of one marine and three freshwater-dependent species from the flatfish family Achiridae, we revealed that functions of fatty acid metabolising enzymes have uniquely and independently evolved by multi-functionalisation or neofunctionalisation in each freshwater species, such that every functional combination of the enzymes has converged to generate complete and functional DHA biosynthetic pathways. Our results demonstrate the elaborate patchwork of fatty acid metabolism and the importance of acquiring DHA biosynthetic function in order for fish to cross the nutritional barrier at the mouth of rivers and colonise freshwater environments."}]},"item_3_description_63":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"19K22329"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_3_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{}}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s42003-020-01242-3","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s42003-020-01242-3","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN研究課題: 熱帯産シタビラメとの雑種化によりDHAを自ら合成可能なヒラメを作る"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22329/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Nature"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/","subitem_relation_type_select":"URI"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23993642","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_62":{"attribute_name":"件名","attribute_value_mlt":[{"subitem_subject":"科学研究費研究成果"}]},"item_3_subject_64":{"attribute_name":"科学研究費研究課題","attribute_value_mlt":[{"subitem_subject":"熱帯産シタビラメとの雑種化によりDHAを自ら合成可能なヒラメを作る"},{"subitem_subject":"Introduction of novel fatty acid desaturase activities by hybridization in flatfishes"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsushita, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyoshi, Kaho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kabeya, Naoki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sanada, Shuwa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yazawa, Ryosuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Haga, Yutaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Satoh, Shuichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Yoji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Strüssmann, Carlos Augusto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Luckenbach, John Adam"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Goro"}],"nameIdentifiers":[{},{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways"}]},"item_type_id":"3","owner":"15","path":["207","208","236","245","416","419","498","499","531"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-10"},"publish_date":"2021-05-10","publish_status":"0","recid":"2097","relation_version_is_last":true,"title":["Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:24:43.755712+00:00"}