{"created":"2023-07-25T09:58:36.895076+00:00","id":1741,"links":{},"metadata":{"_buckets":{"deposit":"81847c29-5b59-4880-9997-42a3351f3f1a"},"_deposit":{"created_by":15,"id":"1741","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"1741"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00001741","sets":["187:191:235","41:356","70:358"]},"author_link":["2835","2842","2112","2837","1460","2848","2828","2860","2849","2838","2844","2855","2832","2840","2852","2843","2841","2858","2853","2861","2833","2857","2846","2836","2831","2829","2834","2850","2839","2851","2856","2854","2845","2859","2830","2847"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"124","bibliographicPageStart":"119","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Nature Genetics"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Flatfish have the most extreme asymmetric body morphology of vertebrates. During metamorphosis, one eye migrates to the contralateral side of the skull, and this migration is accompanied by extensive craniofacial transformations and simultaneous development of lopsided body pigmentation1,2,3,4,5. The evolution of this developmental and physiological innovation remains enigmatic. Comparative genomics of two flatfish and transcriptomic analyses during metamorphosis point to a role for thyroid hormone and retinoic acid signaling, as well as phototransduction pathways. We demonstrate that retinoic acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid hormones, in modulating eye migration. The unexpected expression of the visual opsins from the phototransduction pathway in the skin translates illumination differences and generates retinoic acid gradients that underlie the generation of asymmetry. Identifying the genetic underpinning of this unique developmental process answers long-standing questions about the evolutionary origin of asymmetry, but it also provides insight into the mechanisms that control body shape in vertebrates."}]},"item_3_description_63":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"16H04970"}]},"item_3_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{}}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/ng.3732","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/ng.3732","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN研究課題: ウイルス耐病性責任遺伝子を用いた天然魚における遺伝子選抜育種技術の開発"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16H04970/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"研究代表者: 坂本 崇 (東京海洋大学)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://nrid.nii.ac.jp/ja/nrid/1000040313390/","subitem_relation_type_select":"URI"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1061-4036","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_62":{"attribute_name":"件名","attribute_value_mlt":[{"subitem_subject":"科学研究費研究成果"}]},"item_3_subject_64":{"attribute_name":"科学研究費研究課題","attribute_value_mlt":[{"subitem_subject":"ウイルス耐病性責任遺伝子を用いた天然魚における遺伝子選抜育種技術の開発"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shao, Changwei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bao, Baolong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xie, Zhiyuan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chen, Xinye"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Bo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jia, Xiaodong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yao, Qiulin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ortí, Guillermo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Wenhui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Xihong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamre, Kristin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xu, Juan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Lei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chen, Fangyuan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tian, Yongsheng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Schreiber, Alex 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asymmetry"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:44:13.104315+00:00"}