{"created":"2023-07-25T09:58:36.708474+00:00","id":1738,"links":{},"metadata":{"_buckets":{"deposit":"72910ea3-0a82-4017-9915-0ec94b948af8"},"_deposit":{"created_by":15,"id":"1738","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"1738"},"status":"published"},"_oai":{"id":"oai:oacis.repo.nii.ac.jp:00001738","sets":["187:190:348","41:347","70:349"]},"author_link":["2824","2821","1998","2822","2820","2823"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"231","bibliographicPageStart":"221","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Bioscience, Biotechnology, and Biochemistry"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aplog-1 is a simplified analog of debromoaplysiatoxin (DAT) with potent tumor-promoting and proinflammatory activities. Aplog-1 and DAT exhibited anti-proliferative activities against several human cancer cell lines, whereas aplog-1 did not have tumor-promoting nor proinflammatory activities. We have recently found 10-methyl-aplog-1 (1) to have strong anti-proliferative activity compared with aplog-1. To further investigate the structural factors involved in the tumor-promoting, proinflammatory, and anti-proliferative activities, two dimethyl derivatives of aplog-1 (2, 3) were synthesized, where two methyl groups were installed at positions 4 and 10 or 10 and 12. 10,12-Dimethyl-aplog-1 (2) had stronger inhibitory effects on the growth of several human cancer cell lines than 1 and DAT, but exhibited no tumor-promoting and proinflammatory activities. In contrast, 4,10-dimethyl-aplog-1 (3) displayed weak tumor-promoting and proinflammatory activities along with anti-proliferative activity similar to that of 1 and DAT. Compound 2 would be the optimized seed for anticancer drugs among the simplified analogs of DAT."}]},"item_3_description_63":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"16K01911"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本農芸化学会"}]},"item_3_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/09168451.2015.1091718","subitem_relation_type_select":"DOI"}}]},"item_3_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's Version/PDF (OpenAccess)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/09168451.2015.1091718","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"日本農芸化学会"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jsbba.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN研究課題: 海洋危険生物の有する痛み惹起物質の解明"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K01911/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"研究代表者: 永井 宏史 (東京海洋大学)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://nrid.nii.ac.jp/ja/nrid/1000050291026/","subitem_relation_type_select":"URI"}}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09168451","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10824164","subitem_source_identifier_type":"NCID"}]},"item_3_subject_62":{"attribute_name":"件名","attribute_value_mlt":[{"subitem_subject":"科学研究費研究成果"}]},"item_3_subject_64":{"attribute_name":"科学研究費研究課題","attribute_value_mlt":[{"subitem_subject":"海洋危険生物の有する痛み惹起物質の解明"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikumori, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagita, Ryo C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokuda, Harukuni"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suenaga, Kiyotake"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Irie, Kazuhiro"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-proliferative","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"debromoaplysiatoxin","subitem_subject_scheme":"Other"},{"subitem_subject":"protein kinase C","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor promoter","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead"}]},"item_type_id":"3","owner":"15","path":["347","348","349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-27"},"publish_date":"2019-05-27","publish_status":"0","recid":"1738","relation_version_is_last":true,"title":["Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:44:17.893035+00:00"}