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Visualization of dietary docosahexaenoic acid in whole-body zebrafish using matrix-assisted laser desorption/ionization mass spectrometry imaging
https://oacis.repo.nii.ac.jp/records/2570
https://oacis.repo.nii.ac.jp/records/25704eded197-664a-49cc-81dc-aa74dec9c8a7
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-09-26 | |||||
タイトル | ||||||
タイトル | Visualization of dietary docosahexaenoic acid in whole-body zebrafish using matrix-assisted laser desorption/ionization mass spectrometry imaging | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | lipid metabolism, docosahexaenoic acid, zebrafish, stable isotope, MALDI-MS imaging | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Yoshinaga, Kazuaki
× Yoshinaga, Kazuaki× Usami, Yuka× Yoshinaga-Kiriake, Aya× Shikano, Hitomi× Taira, Shu× Nagasaka, Reiko× Tanaka, Seiya× Gotoh, Naohiro |
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書誌情報 |
The Journal of Nutritional Biochemistry 巻 100, p. 108897, 発行日 2022-02 |
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抄録 | ||||||
内容記述 | Zebrafish models have been developed for several studies involving lipid metabolism and lipid-related diseases. In the present study, the migration of dietary docosahexaenoic acid (DHA) in whole-body zebrafish was estimated by stable-isotope tracer and matrix-assisted laser desorption/ionization mass spectrometry imaging. Administration of 1-13C-2,2-D2-labeled DHA ((+3)DHA) ethyl ester to male zebrafish was conducted to evaluate its accumulation, migration, and distribution in the body. The (+3)DHA content in the body of zebrafish after administering (+3)DHA for 10 and 15 d was significantly higher than that in the control group. (+3)DHA was observed as a constituent of phosphatidylcholine (PC) in the intestine of zebrafish that were administered (+3)DHA for 5 and 10 d. (+3)DHA-containing PC tended to accumulate in the intestines of zebrafish administered (+3)DHA for 1 d, indicating that recombination of (+3)DHA from ethyl ester to PC occurs quickly at intestine. After administration for 15 d, (+3)DHA-containing PC accumulated in the intestine, liver, and muscle of whole-body zebrafish. In contrast, (+3)DHA-containing PC was not detected in the brain. These results showed that dietary DHA is initially constructed into PC as a structural component of intestinal cell membranes and gradually migrates into peripheral tissues such as muscle. |
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内容記述 | ||||||
内容記述 | 公開日: 2022-12-02 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0955-2863 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10748929 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 34748923 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.jnutbio.2021.108897 | |||||
権利 | ||||||
権利情報 | (c) 2022 Elsevier B.V.. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in https://doi.org/10.1016/j.jnutbio.2021.108897 | |||||
情報源 | ||||||
関連識別子 | https://www.sciencedirect.com/science/article/am/pii/S095528632100317X | |||||
関連名称 | Author's Accepted Manuscript Version/PDF (Available on: 2022-12-02) | |||||
情報源 | ||||||
関連識別子 | https://www.elsevier.com/ja-jp | |||||
関連名称 | Elsevier B.V. | |||||
出版者 | ||||||
出版者 | Elsevier B.V. |