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Cell-mediated immune response against mycolic acids of Mycobacteroides salmoniphilum in rainbow trout Oncorhynchus mykiss
https://oacis.repo.nii.ac.jp/records/2567
https://oacis.repo.nii.ac.jp/records/2567863db76e-89cc-4e13-b8ed-f18c1bf3f5e9
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-09-26 | |||||
タイトル | ||||||
タイトル | Cell-mediated immune response against mycolic acids of Mycobacteroides salmoniphilum in rainbow trout Oncorhynchus mykiss | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Mycobacteriosis, Rainbow trout, Mycolic acids, Mycobacteroides salmoniphilum, Cell-mediated immunity | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Matsumoto, Megumi
× Matsumoto, Megumi× Fischer, Uwe× Sano, Motohiko× Kato, Goshi |
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書誌情報 |
Developmental & Comparative Immunology 巻 124, p. 104195, 発行日 2021-11 |
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抄録 | ||||||
内容記述 | Mycobacteriosis caused by Mycobacterium spp. causes economic damages to the world aquaculture industry. In mammals, mycolic acids contained in the cell wall of Mycobacterium spp. are presented by CD1b molecule as lipid antigens and induce cell-mediated immunity (CMI). Here, we investigated CMI responses against the mycolic acids of Mycobacterioides salmoniphilum in a CD1-lacking teleost fish, rainbow trout. After stimulation of trout leukocytes with mycolic acids, the number and percentage of CD8α+ T cells increased. Fish immunized with mycolic acids showed an up-regulation of IFN-γ. Further, in vitro re-stimulation of leukocytes derived from immunized fish resulted in proliferation of CD8α+ cells. These data suggest that mycolic acids are recognized as lipid antigens resulting in an activation of rainbow trout CD8α+ cells and up-regulation of the Th1 cytokine IFN-γ. The mycolic acids are promising candidates for vaccines to activate CD8α+ T cells against fish mycobacteriosis. |
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内容記述 | ||||||
内容記述 | 公開日: 2022-07-05 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0145-305X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00627870 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 34217784 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.dci.2021.104195 | |||||
権利 | ||||||
権利情報 | (c) 2021 Elsevier B.V.. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in https://doi.org/10.1016/j.dci.2021.104195 | |||||
情報源 | ||||||
関連識別子 | https://www.sciencedirect.com/science/article/am/pii/S0145305X21002032 | |||||
関連名称 | Author's Accepted Manuscript Version/PDF (Available on: 2022-07-05) | |||||
情報源 | ||||||
関連識別子 | https://www.elsevier.com/ja-jp | |||||
関連名称 | Elsevier B.V. | |||||
出版者 | ||||||
出版者 | Elsevier B.V. |