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Hyaluromycin, a New Hyaluronidase Inhibitor of Polyketide Origin from Marine Streptomyces sp.
https://oacis.repo.nii.ac.jp/records/2387
https://oacis.repo.nii.ac.jp/records/23873ce52517-31b0-46d0-849d-aa6595d6d059
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-08 | |||||
タイトル | ||||||
タイトル | Hyaluromycin, a New Hyaluronidase Inhibitor of Polyketide Origin from Marine Streptomyces sp. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | rubromycin, hyaluronidase inhibitor, marine actinomycetes, Streptomyces, 2-amino-3-hydroxycyclopent-2-enone | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Harunari, Enjuro
× Harunari, Enjuro× Imada, Chiaki× Igarashi, Yasuhiro× Fukuda, Takao× Terahara, Takeshi× Kobayashi, Takeshi |
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書誌情報 |
Marine Drugs 巻 12, 号 1, p. 491-507, 発行日 2014-01-21 |
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抄録 | ||||||
内容記述 | Hyaluromycin (1), a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived Streptomyces sp. as a HAase inhibitor on the basis of HAase activity screening. The structure of 1 was elucidated through the interpretation of NMR data for the compound and its 3″-O-methyl derivative in combination with an incorporation experiment with [1,2-13C2]acetate. The compound’s absolute configuration was determined by the comparison of its circular dichroism (CD) spectrum with those of other rubromycins. Hyaluromycin (1) consists of a γ-rubromycin core structure possessing a 2-amino-3-hydroxycyclopent-2-enone (C5N) unit as an amide substituent of the carboxyl function; both structural units have been reported only from actinomycetes. Hyaluromycin (1) displayed approximately 25-fold more potent hyaluronidase inhibitory activity against hyaluronidase than did glycyrrhizin, a known inhibitor of plant origin. |
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書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1203626X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3390/md12010491 | |||||
情報源 | ||||||
関連識別子 | https://doi.org/10.3390/md12010491 | |||||
関連名称 | Publisher's Version/PDF (OpenAccess) | |||||
情報源 | ||||||
関連識別子 | https://www.mdpi.com/ | |||||
関連名称 | MDPI | |||||
出版者 | ||||||
出版者 | MDPI |