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Development of an in vivo-mimic silkworm infection model with Mycobacterium avium complex
https://oacis.repo.nii.ac.jp/records/2368
https://oacis.repo.nii.ac.jp/records/2368c86bfe8e-ec55-4c2d-a602-c09616f55a48
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-01 | |||||
タイトル | ||||||
タイトル | Development of an in vivo-mimic silkworm infection model with Mycobacterium avium complex | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | silkworm infection model, antibiotics, Mycobacterium avium complex (MAC), nontuberculosis mycobacteria (NTM), natural product, microbial origin | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Yagi, Akiho
× Yagi, Akiho× Yamazaki, Hiroyuki× Terahara, Takeshi× Yang, Taehui× Hamamoto, Hiroshi× Imada, Chiaki× Tomoda, Hiroshi× Uchida, Ryuji |
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書誌情報 |
Drug Discoveries & Therapeutics 巻 14, 号 6, p. 287-295, 発行日 2020-12-31 |
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抄録 | ||||||
内容記述 | In vivo-mimic silkworm infection models with Mycobacterium avium and Mycobacterium intracellulare were newly established to evaluate the therapeutic effects of anti-M. avium complex (MAC) antibiotics. Silkworms raised at 37°C died within 72 hours of an injection of M. avium or M.intracellulare (2.5 × 107 colony-forming unit (CFU)/larva·g) into the hemolymph. Clinical anti-mycobacterial (tuberculosis) antibiotics were evaluated under these conditions. Clarithromycin, kanamycin, streptomycin, amikacin, and ciprofloxacin exerted therapeutic effects in a dose-dependent manner, which was consistent with those in the mouse model. Furthermore, three effective actinomycete culture broths were selected in the screening program of our microbial broth library using the silkworm model, and four active metabolites, ohmyungsamycins A and B (1 and 2), chartreusin (3), and griseoviridin (4), were identified. Among these compounds, 1 showed the lowest 50% effective dose (ED50) value (8.5 µg/larva·g), while 3 had the best ED50/minimum inhibitory concentration (MIC) ratio (7.4). These results indicate that silkworm models are a useful tool for identifying anti-MAC antibiotics candidates with veritable therapeutic effects. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1881-7831 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12524875 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.5582/ddt.2020.03099 | |||||
情報源 | ||||||
関連識別子 | https://doi.org/10.5582/ddt.2020.03099 | |||||
関連名称 | Publisher's Version/PDF (OpenAccess) | |||||
情報源 | ||||||
関連識別子 | http://www.iacmhr.com/ | |||||
関連名称 | IACMHR | |||||
情報源 | ||||||
関連識別子 | https://www.pharm.sdu.edu.cn/english/index.htm | |||||
関連名称 | SDU-DDSC | |||||
出版者 | ||||||
出版者 | IACMHR | |||||
出版者 | ||||||
出版者 | SDU-DDSC |