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Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process
https://oacis.repo.nii.ac.jp/records/2228
https://oacis.repo.nii.ac.jp/records/2228d33f5ae4-0e5e-4a91-83d9-169d7d972cdf
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-22 | |||||
| タイトル | ||||||
| タイトル | Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小祝, 敬一郎
× 小祝, 敬一郎× Koyama, Takashi× Tsuda, Soichiro× Toyoda, Atsushi× Kikuchi, Kiyoshi× Suzuki, Hiroaki× Kawano, Ryuji |
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| 書誌情報 |
Tools and Resource 巻 10, p. e66954, 発行日 2021-01-16 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Crustacean aquaculture is expected to be a major source of fishery commodities in the near future. Hemocytes are key players of the immune system in shrimps; however, their classification, maturation, and differentiation are still under debate. To date, only discrete and inconsistent information on the classification of shrimp hemocytes has been reported, showing that the morphological characteristics are not sufficient to resolve their actual roles. Our present study using single-cell RNA sequencing revealed six types of hemocytes of Marsupenaeus japonicus based on their transcriptional profiles. We identified markers of each subpopulation and predicted the differentiation pathways involved in their maturation. We also predicted cell growth factors that might play crucial roles in hemocyte differentiation. Different immune roles among these subpopulations were suggested from the analysis of differentially expressed immune-related genes. These results provide a unified classification of shrimp hemocytes, which improves the understanding of its immune system. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.7554/eLife.66954 | |||||
| 情報源 | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.7554/eLife.66954 | |||||
| 関連名称 | Publisher's Version/PDF (OpenAccess) | |||||
| 情報源 | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://elifesciences.org/ | |||||
| 関連名称 | eLife | |||||
| 出版者 | ||||||
| 出版者 | eLife | |||||
