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Cardio-Metabolic Disease Risks and Their Associations with Circulating 25-Hydroxyvitamin D and Omega-3 Levels in South Asian and White Canadians
https://oacis.repo.nii.ac.jp/records/1796
https://oacis.repo.nii.ac.jp/records/1796f719fa6a-9a29-4e46-b7cd-bb5996d1d9c1
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-08 | |||||
タイトル | ||||||
タイトル | Cardio-Metabolic Disease Risks and Their Associations with Circulating 25-Hydroxyvitamin D and Omega-3 Levels in South Asian and White Canadians | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Cardiovascular diseases, Ethnic epidemiology, Vitamin D, Diabetes mellitus, Cholesterol, Insulin, Health risk analysis, Leptin | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Xiao, Chao-Wu
× Xiao, Chao-Wu× Wood, Carla M.× Swist, Eleonora× Nagasaka, Reiko× Sarafin, Kurtis× Gagnon, Claude× Fernandez, Lois× Faucher, Sylvie× Wu, Hong-Xing× Kenney, Laura× Ratnayake, Walisundera M. N. |
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書誌情報 |
PLOS ONE 巻 11, 号 1, p. e0147648, 発行日 2016-01-25 |
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抄録 | ||||||
内容記述 | Objectives: This study compared cardio-metabolic disease risk factors and their associations with serum vitamin D and omega-3 status in South Asian (SAC) and White Canadians (WC) living in Canada’s capital region. | |||||
抄録 | ||||||
内容記述 | Methods: Fasting blood samples were taken from 235 SAC and 279 WC aged 20 to 79 years in Ottawa, and 22 risk factors were measured. | |||||
抄録 | ||||||
内容記述 | Results: SAC men and women had significantly higher fasting glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), apolipoprotein B (ApoB), ratios of total (TC) to HDL cholesterol (HDLC) and ApoB to ApoA1, leptin, E-selectin, P-selectin, ICAM-1 and omega-3 (p < 0.05), but lower HDLC, ApoA1, vitamin D levels than WC (p < 0.05). SAC women had higher CRP and VEGF than WC women. Adequate (50–74.9 nmol/L) or optimal (≥ 75 nmol/L) levels of 25(OH)D were associated with lower BMI, glucose, insulin, HOMA-IR, TG, TC, low density lipoprotein cholesterol (LDLC), ApoB/ApoA1 ratio, CRP, leptin, and higher HDLC, ApoA1, omega-3 index, L-selectin levels in WC, but not in SAC. Intermediate (>4%-<8%) or high (≥ 8%) levels of omega-3 indices were related to lower E-selectin, P-selectin, ICAM-1 and higher HDLC, 25(OH)D levels in WC, but not in SAC. The BMIs of ≤ 25 kg/m2 were related to lower LDLC, ApoB, VEGF, creatinine and higher 25(OH)D in WC, but not in SAC. | |||||
抄録 | ||||||
内容記述 | Conclusions: The associations of vitamin D, omega-3 status, BMI and risk factors were more profound in the WC than SAC. Compared to WC, vitamin D status and omega-3 index may not be good predictive risk factors for the prevalence of CVD and diabetes in SAC. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1371/journal.pone.0147648 | |||||
情報源 | ||||||
関連識別子 | https://doi.org/10.1371/journal.pone.0147648 | |||||
関連名称 | Publisher's Version/PDF (OpenAccess) | |||||
情報源 | ||||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25850142/ | |||||
関連名称 | KAKEN研究課題: エネルギー代謝が及ぼすストレス応答と骨格筋代謝とのネットワーク解明 | |||||
情報源 | ||||||
関連識別子 | https://nrid.nii.ac.jp/ja/nrid/1000090444132/ | |||||
関連名称 | 研究代表者: 長阪 玲子 (東京海洋大学) | |||||
件名 | ||||||
主題 | 科学研究費研究成果 | |||||
出版者 | ||||||
出版者 | PLOS | |||||
科学研究費研究課題 | ||||||
主題 | エネルギー代謝が及ぼすストレス応答と骨格筋代謝とのネットワーク解明 | |||||
科学研究費研究課題 | ||||||
主題 | Elucidation of the network of stress responses and skeletal muscle metabolisms by fish energy metabolisms. | |||||
研究課題番号 | ||||||
内容記述 | 25850142 |