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Passive immunisation of goldfish with the serum of those surviving a Cyprinid herpesvirus 2 infection after high temperature water treatment
https://oacis.repo.nii.ac.jp/records/1780
https://oacis.repo.nii.ac.jp/records/17808cce42b0-497f-4e00-ae28-170d57146339
名前 / ファイル | ライセンス | アクション |
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15H04544_BEAFP_37-2-62 (319.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-24 | |||||
タイトル | ||||||
タイトル | Passive immunisation of goldfish with the serum of those surviving a Cyprinid herpesvirus 2 infection after high temperature water treatment | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Nanjo, Azusa
× Nanjo, Azusa× Shibata, Tomoya× Yoshii, Keisuke× Shibasaki, Yasuhiro× Nakanishi, Teruyuki× Tanaka, Mikio× Kato, Goshi× Sano, Motohiko |
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書誌情報 |
Bulletin of the European Association of Fish Pathologists 巻 37, 号 2, p. 62-69, 発行日 2017-04-01 |
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抄録 | ||||||
内容記述 | Herpesviral haematopoietic necrosis of goldfish caused by cyprinid herpesvirus 2 (CyHV-2) can be controlled by raising water temperature to a virus non-permissive temperature of 34℃. Consequently, the goldfish can survive and acquire resistance to the disease; the underlying mechanism of acquired resistance, however, remains unclear. In this study, we investigated serological changes in the surviving goldfish, with a focus on their humoral immunity, and examined whether sera of the surviving goldfish conferred passive immunity to naive goldfish. Levels of the anti-CyHV-2 antibodies in 8 of the 9 survivors measured via ELISA were higher than those in control fish. Neutralising antibodies were detected in the sera of 2 survivors, but no direct correlation was observed between ELISA optical density value and neutralising antibody titer. Passive immunisation tests showed that recipients injected with the serum containing neutralising antibodies showed higher survival rates than the control group. The sera from 6 other survivors showed no effect on the recipient's mortality regardless of anti-CyHV-2 antibody levels. These results suggest that neutralising antibodies can contribute to acquired immunity in survivors, and other protective factors, including cell-mediated immunity, may work in the survivors that show no detectable neutralising antibodies. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01080288 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11588883 | |||||
権利 | ||||||
権利情報 | © EAFP.org | |||||
情報源 | ||||||
関連識別子 | https://eafp.org/bulletin-contents-37-2/ | |||||
関連名称 | Publisher's Version | |||||
情報源 | ||||||
関連識別子 | https://eafp.org/ | |||||
関連名称 | European Association of Fish Pathologists | |||||
情報源 | ||||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H04544/ | |||||
関連名称 | KAKEN研究課題: キンギョヘルペスウイルスに対する耐病性機構の解明による選抜育種バイオマーカー開発 | |||||
情報源 | ||||||
関連識別子 | https://nrid.nii.ac.jp/ja/nrid/1000000372053/ | |||||
関連名称 | 研究代表者: 佐野元彦 (東京海洋大学) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
件名 | ||||||
主題 | 科学研究費研究成果 | |||||
出版者 | ||||||
出版者 | European Association of Fish Pathologists | |||||
科学研究費研究課題 | ||||||
主題 | キンギョヘルペスウイルスに対する耐病性機構の解明による選抜育種バイオマーカー開発 | |||||
科学研究費研究課題 | ||||||
主題 | Development of biological marker for breeding goldfish strain resistant to herpesviral hematopoietic necrosis | |||||
研究課題番号 | ||||||
内容記述 | 15H04544 |