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Nomimicins B–D, new tetronate-class polyketides from amarine-derived actinomycete of the genus Actinomadura
https://oacis.repo.nii.ac.jp/records/2230
https://oacis.repo.nii.ac.jp/records/22309a7e6917-0b24-43dd-8482-afcf8496d2fe
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-09-22 | |||||
タイトル | ||||||
タイトル | Nomimicins B–D, new tetronate-class polyketides from amarine-derived actinomycete of the genus Actinomadura | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Actinomadura, nomimicin, polyketide, spirotetronate | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Zhang, Zhiwei
× Zhang, Zhiwei× Zhou, Tao× Yang, Taehui× Fukaya, Keisuke× Harunari, Enjuro× Saito, Shun× Yamada, Katsuhisa× Imada, Chiaki× Urabe, Daisuke× Igarashi, Yasuhiro |
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書誌情報 |
Journal of Organic Chemistry 巻 17, p. 2194-2202, 発行日 2021-08-27 |
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抄録 | ||||||
内容記述 | Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolat-ed from the culture extract of Actinomadura sp. AKA43 collected from floating particles in the deep-sea water of Sagami Bay,Japan. The structures of nomimicins B, C, and D were elucidated through the interpretation of NMR and MS analytical data, andthe absolute configuration was determined by combination of NOESY/ROESY and ECD analyses. Nomimicins B, C, and Dshowed antimicrobial activity against Gram-positive bacteria, Kocuria rhizophila and Bacillus subtilis, with MIC values in therange of 6.5 to 12.5 μg/mL. Nomimicins B and C also displayed cytotoxicity against P388 murine leukemia cells with IC50 valuesof 33 and 89 μM, respectively. | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3762/bjoc.17.141 | |||||
情報源 | ||||||
関連識別子 | https://doi.org/10.3762/bjoc.17.141 | |||||
関連名称 | Publisher's Version/PDF (OpenAccess) | |||||
情報源 | ||||||
関連識別子 | https://www.beilstein-journals.org/bjoc/home | |||||
関連名称 | Beilstein | |||||
出版者 | ||||||
出版者 | Beilstein |