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Linear chain aldehydes evoke calcium responses in B16 melanoma cells
https://oacis.repo.nii.ac.jp/records/1993
https://oacis.repo.nii.ac.jp/records/1993afed89f4-9fec-4f79-8840-7ddeff2f30b9
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-09-28 | |||||
タイトル | ||||||
タイトル | Linear chain aldehydes evoke calcium responses in B16 melanoma cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | B16 melanoma, oxidative stress, lipid peroxidation, hexanal, calcium response | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
著者 |
Ishikawa, Yuki
× Ishikawa, Yuki× Ohara, Kazuyuki× Ohshima, Toshiaki× Ushio, Hideki |
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書誌情報 |
EXCLI Journal : Experimental and Clinical Sciences 巻 10, p. 303-311, 発行日 2011-09 |
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抄録 | ||||||
内容記述 | Oxidative stress is involved in various physiological impairing stages, such as aging, diabetes, atherosclerosis, cirrhosis, and neurological disorders. Recent research indicates that aldehyde compounds derived from oxidized lipids increase in cancer patients compared to healthy individuals. Among of them, hexanal, a six-carbon liner chain aldehyde, is commonly found in cancer patients. Lipid oxidation products including aldehydes are in general chemically unstable and react with biological molecules such as proteins. The purpose of this study is to investigate effects of lipid-derived aldehydes and the related compounds on intracellular Ca2+ responses in B16 melanoma cells. Hexanal-induced [Ca2+]i elevation is observed in B16 cells in a dose dependent manner, but [Ca2+]i changes were observed neither in 3T3-L1 cells nor Caco-2 cells. Propanal, a chain length analogue of hexanal, elicited no change in [Ca2+]i, but nonanal initiated [Ca2+]i increases. Analogue compounds of hexanal failed to induce [Ca2+]i elevation. Furthermore, unsaturated aldehydes known as TRPA1 channel agonists also failed to alter [Ca2+]i levels in B16 melanoma cells. Pharmacological spectra using inhibitors against intracellular Ca2+ signaling suggest that hexanal-induced [Ca2+]i responses in B16 cells might be involved in TRP channels other than TRPA1. Our results suggest that saturated aliphatic chain aldehydes would be novel compounds for initiating [Ca2+]i increases through very strict recognitions of chain saturation, aldehydic base structures, and chain lengths in B16 melanoma cells. B16 cells would have sensing mechanisms for oxidative status and/or metabolic activities in their growth environment. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1611-2156 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00117901 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29033711 | |||||
情報源 | ||||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611634/pdf/EXCLI-10-303.pdf | |||||
関連名称 | Publisher's Version/PDF (OpenAccess) | |||||
情報源 | ||||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/ | |||||
関連名称 | PMC | |||||
論文ID(NAID) | ||||||
識別子タイプ | NAID | |||||
関連識別子 | 40018907929 | |||||
出版者 | ||||||
出版者 | PMC |